Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-B27 subtypes among the Chukotka Native groups

M Y Krylov1, J D Reveille, L I Alexeeva

  • 1Department of Epidemiology and Genetics of Rheumatic Diseases, Institute of Rheumatology of RAMS, Moscow, Russia.

Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1995
PubMed
Summary

Chukotka natives predominantly carry the HLA-B*2705 subtype, similar to Caucasians, despite higher rates of HLA-B27 and spondyloarthropathies. This genetic finding suggests closer ties to Caucasian populations than Oriental ones.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remission and low disease activity state (LDAS) are protective of intermediate and long-term outcomes in SLE patients. Results from LUMINA (LXXVIII), a multiethnic, multicenter US cohort.

Lupus·2019
Same author

A unique antiphospholipid assay recognizing phospholipid mixture compared with criteria antiphospholipid immunoassays in lupus patients.

Lupus·2016
Same author

Factors associated with disease expression patterns in systemic lupus erythematosus patients: results from LUMINA (LXXVII), a multiethnic US cohort.

Lupus·2016
Same author

Association study of genes related to bone formation and resorption and the extent of radiographic change in ankylosing spondylitis.

Annals of the rheumatic diseases·2014
Same author

Effects of statins on proinflammatory/prothrombotic biomarkers and on disease activity scores in SLE patients: data from LUMINA (LXXVI), a multi-ethnic US cohort.

Clinical and experimental rheumatology·2014
Same author

Association between copy number variations of HLA-DQA1 and ankylosing spondylitis in the Chinese Han population.

Genes and immunity·2013

Area of Science:

  • Immunogenetics
  • Population Genetics
  • Anthropology

Background:

  • The Chukotka native population exhibits elevated frequencies of Human Leukocyte Antigen B27 (HLA-B27) and spondyloarthropathies compared to Russian Caucasians.
  • Understanding the distribution of HLA-B27 subtypes is crucial for investigating the genetic basis of these conditions in diverse populations.

Purpose of the Study:

  • To determine the relative frequencies of known HLA-B27 subtypes within the HLA-B27 positive Chukotka native population.
  • To compare the HLA-B27 subtype profile of Chukotka natives with other ethnic groups, particularly Caucasians and Orientals.

Main Methods:

  • DNA samples from 86 HLA-B27 positive Chukotka individuals were analyzed.
  • Oligotyping was employed to amplify and type the second and third exons of the HLA-B27 gene.

Related Experiment Videos

Main Results:

  • The predominant HLA-B27 subtype found was HLA-B*2705 in all but one individual.
  • One Eskimo individual was found to have the HLA-B*2702 subtype.
  • The HLA-B*2704 subtype, common in Oriental populations, was not detected.

Conclusions:

  • The HLA-B27 subtype profile of Chukotka natives, primarily HLA-B*2705, aligns more closely with Caucasian populations than Oriental ones.
  • This genetic similarity may offer insights into the susceptibility and presentation of spondyloarthropathies in this indigenous group.