[Study of DNA content, immunophenotype in childhood non-Hodgkin's lymphomas]

The DNA content, immunophenotypes and Ag-NOR of 63 cases of childhood NHL have been studied with flow cytometry and immunohistochemistry. The results showed that the incidence of aneuploidy, the numbers of Ag-NOR and PI increased significantly with increasing histological grade. The numbers of PI were also a valuable prognostic parameter. There was a positive correlation between the numbers of PI and AgNOR. No significant correlation was seen between the survival rates of diploid and aneuploid tumors. The highest to lowest survival rates being in the sequence of unclassified tumors, T-cell tumors and B-cell tumors.