Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[A pathological comparison between Hirschsprung's enterocolitis and neonate necrotizing enterocolitis]

Z Zhang¹, Y She, Y Wang

¹Department of Pathology, Xinhua Hospital, Shanghai Second Medical University.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology

|October 1, 1995

Summary

Necrotizing enterocolitis (NEC) involves more severe intestinal lesions, bleeding, and inflammation than Hirschsprung

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multi-phase computed tomography angiography combined with inflammation index to predict clinical functional prognosis in patients with acute ischemic stroke.

Clinical radiology·2024

Same author

Systematic analysis of prophages carried by Porphyromonas gingivalis.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2023

Same author

Ghrelin to obestatin ratio in maternal serum in pregnancies complicated by intrauterine growth restriction.

Clinical and experimental obstetrics & gynecology·2018

Same author

Robust reduced-rank regression.

Biometrika·2018

Same author

Effects of graded levels of microbial phytase on apparent total tract digestibility of calcium and phosphorus and standardized total tract digestibility of phosphorus in four sources of canola meal and in soybean meal fed to growing pigs.

Journal of animal science·2017

Same author

[Research progress of PD-1/PD-L1 pathway in non-small cell lung cancer with EGFR].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2017

Area of Science:

Pediatric Surgery
Gastroenterology
Neonatal Pathology

Background:

Hirschsprung's enterocolitis (HD) and necrotizing enterocolitis (NEC) are critical neonatal intestinal conditions.
Distinguishing between HD and NEC is crucial for appropriate clinical management and outcomes.

Purpose of the Study:

To compare the pathological findings of neonatal HD and NEC.
To investigate the potential pathogenesis of both HD and NEC through animal experimentation.

Main Methods:

Analysis of autopsy records from 9 neonate HD cases and 16 neonate NEC cases.
Conducted 21 animal experiments to explore the development of HD and NEC.

Main Results:

NEC lesions were found to be more extensive than HD lesions.

Related Experiment Videos

NEC exhibited more severe bleeding and inflammation compared to HD.

A preliminary hypothesis for HD pathogenesis involves distal obstruction, proximal distension, ischemia, and bacterial infiltration.

A preliminary hypothesis for NEC pathogenesis involves neonatal asphyxia/shock, intestinal ischemia, immunoallergic reactions, and pathogenic enterobacteria infiltration.

Conclusions:

NEC presents with more severe pathological manifestations than HD.
Proposed distinct etiological pathways for HD and NEC, involving mechanical obstruction and ischemia for HD, and ischemic-reperfusion injury and immune factors for NEC.