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Immunoglobulin depositions in peripheral nerves in polymyositis
Summary
Immunoglobulin and complement deposits in peripheral nerves suggest a role in polymyositis pathogenesis. This immunocytochemical study highlights potential mechanisms in nerve involvement for polymyositis patients.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Polymyositis is an inflammatory myopathy.
- Peripheral nerve involvement can occur in polymyositis.
Purpose of the Study:
- To investigate the immunopathological basis of peripheral nerve involvement in polymyositis.
Main Methods:
- Immunocytochemistry was used on 6 peripheral nerve specimens from polymyositis cases.
Main Results:
- Depositions of IgG, IgM, IgA, and C3 were observed.
- These deposits were located in the epineurium, perineurium, and capillary walls.
Conclusions:
- Immunoglobulin deposition and complement-mediated reactions are implicated in the pathogenesis of polymyositis with peripheral nerve involvement.