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Lymphatic and venous function in lipoedema

C A Harwood1, R H Bull, J Evans

  • 1Department of Dermatology, St George's Hospital, London, U.K.

The British Journal of Dermatology
|January 1, 1996
PubMed
Summary
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Lipoedema, a condition causing leg swelling in women, is not primarily caused by lymphatic or venous dysfunction. This study suggests it

Area of Science:

  • Vascular Biology
  • Dermatology
  • Medical Research

Background:

  • Lipoedema causes bilateral leg enlargement in women, often mistaken for abnormal fat deposition with edema.
  • The exact mechanisms behind edema formation in lipoedema remain unclear.
  • Investigating potential lymphatic or venous dysfunction is crucial for understanding lipoedema pathogenesis.

Purpose of the Study:

  • To evaluate the role of lymphatic and venous dysfunction in lipoedema.
  • To differentiate lipoedema from primary lymphoedema and healthy states.

Main Methods:

  • Photoplethysmography for venous function assessment.
  • Quantitative lymphoscintigraphy for lymphatic function assessment.
  • Comparison with primary lymphoedema patients and healthy volunteers.

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Main Results:

  • Minor venous function abnormalities in 2 out of 10 lipoedema patients.
  • Impaired lymphatic function in 1 patient (moderate) and 7 patients (marginal).
  • Lymphatic impairment in lipoedema did not reach the severity observed in primary lymphoedema.

Conclusions:

  • Lipoedema is a distinct clinical entity.
  • It is best classified as a lipodystrophy.
  • Lipoedema is not a direct consequence of primary venous or lymphatic insufficiency.