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Fixed drug eruption due to ciprofloxacin
1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
The British Journal of Dermatology
|January 1, 1996
Summary
Fixed drug eruption (FDE) from ciprofloxacin is increasingly recognized. This study highlights seven cases, suggesting ciprofloxacin may become a common cause of FDE with its widespread use.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Fixed drug eruption (FDE) is a specific type of adverse drug reaction.
- Ciprofloxacin is a widely prescribed fluoroquinolone antibiotic.
Observation:
- Seven cases of fixed drug eruption (FDE) attributed to ciprofloxacin were observed.
- Rechallenge confirmed ciprofloxacin as the causative agent in five patients.
- Two patients presented with isolated and prominent lip involvement.
Findings:
- These seven cases constituted 8.75% of all FDE cases observed between 1992-1993.
- Previous reports of ciprofloxacin-induced FDE are rare, with only one case documented.
- The frequency of FDE due to ciprofloxacin appears to be increasing.
Implications:
- Widespread ciprofloxacin use may lead to a rise in its incidence as a cause of FDE.
- Clinicians should consider ciprofloxacin in the differential diagnosis of FDE, especially with lip involvement.
- Further pharmacovigilance is warranted to monitor FDE associated with ciprofloxacin.