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Fixed drug eruption due to ciprofloxacin
1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
We describe seven patients with fixed drug eruption (FDE) due to ciprofloxacin, five confirmed by rechallenge. These cases make up 8.75% of all cases of FDE seen by us during 1992-93. Isolated, and striking involvement of the lips was seen in two patients. To our knowledge, only a single case of FDE to ciprofloxacin previously has been reported. Our experience suggests that, with widespread use, ciprofloxacin could become one of the common drugs causing FDE.
Insights
Fixed drug eruption (FDE) from ciprofloxacin is increasingly recognized. This study highlights seven cases, suggesting ciprofloxacin may become a common cause of FDE with its widespread use.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Fixed drug eruption (FDE) is a specific type of adverse drug reaction.
- Ciprofloxacin is a widely prescribed fluoroquinolone antibiotic.
Observation:
- Seven cases of fixed drug eruption (FDE) attributed to ciprofloxacin were observed.
- Rechallenge confirmed ciprofloxacin as the causative agent in five patients.
- Two patients presented with isolated and prominent lip involvement.
Findings:
- These seven cases constituted 8.75% of all FDE cases observed between 1992-1993.
- Previous reports of ciprofloxacin-induced FDE are rare, with only one case documented.
- The frequency of FDE due to ciprofloxacin appears to be increasing.
Implications:
- Widespread ciprofloxacin use may lead to a rise in its incidence as a cause of FDE.
- Clinicians should consider ciprofloxacin in the differential diagnosis of FDE, especially with lip involvement.
- Further pharmacovigilance is warranted to monitor FDE associated with ciprofloxacin.