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[Diarrhea caused by antibiotic therapy]

L Beaugerie1

  • 1Service d'hépato-gastro-entérologie et de nutrition, Hôpital Rothschild, Paris.

La Revue Du Praticien
|January 15, 1996
PubMed
Summary

Antibiotic treatment can cause diarrhoea in 30% of patients by disrupting gut flora. This disruption can lead to Clostridium difficile infection, causing a range of illnesses from mild diarrhoea to severe colitis.

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Area of Science:

  • Microbiology and Infectious Diseases
  • Gastroenterology
  • Pharmacology

Context:

  • Antimicrobial agents are widely used, with up to 30% of patients experiencing diarrhoea.
  • Diarrhoea is often a benign, transient disruption of the normal colonic flora.
  • Antibiotic-induced dysbiosis can lead to pathogen colonization, notably Clostridium difficile.

Purpose:

  • To highlight the incidence and nature of antibiotic-associated diarrhoea.
  • To identify Clostridium difficile as a significant pathogen in this context.
  • To describe the spectrum of diseases caused by C. difficile intestinal infection.

Summary:

  • Antibiotic use frequently causes diarrhoea due to alterations in gut microbiota.
  • Clostridium difficile is a key opportunistic pathogen that can proliferate following antibiotic treatment.
  • Infections range from mild diarrhoea to severe, potentially life-threatening pseudomembranous colitis.

Impact:

  • Understanding this link is crucial for clinical management of patients on antibiotics.
  • Highlights the importance of monitoring for C. difficile infection in cases of antibiotic-associated diarrhoea.
  • Informs strategies for preventing and treating severe outcomes like pseudomembranous colitis.

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