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Histochemical and ultrastructural study of diffuse melanoderma after bone marrow transplantation
S Aractingi1, A Janin, A Devergie
1Clinique des maladies cutanées, Hôpital Saint-Louis, Paris, France.
The British Journal of Dermatology
|February 1, 1996
Summary
Two bone marrow transplant patients developed unusual diffuse skin darkening (melanoderma) after graft-versus-host disease (GVHD). This rare presentation suggests melanoderma can be a feature of cutaneous GVHD in pigmented individuals.
Area of Science:
- Dermatology
- Hematology
- Immunology
Background:
- Cutaneous graft-versus-host disease (GVHD) commonly causes hyperpigmentation, typically localized to specific lesion sites.
- Diffuse melanoderma is an uncommon presentation of GVHD following allogeneic bone marrow transplantation.