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Related Experiment Videos

Cortisol excretion in essential hypertension

A P Heaney1, T Ferguson, B Sheridan

  • 1Sir George E Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland.

Journal of Human Hypertension
|December 1, 1995
PubMed
Summary

This study investigated cortisol excretion in essential hypertension. Researchers found no significant differences in urinary free cortisol or cortisol to creatinine ratios between hypertensive and normotensive individuals, suggesting normal adrenal cortex function in hypertension.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Hypertension Research

Background:

  • Essential hypertension is a complex condition with potential links to adrenal cortex dysfunction.
  • Previous research suggests possible abnormalities in adrenal function in hypertensive patients.

Purpose of the Study:

  • To investigate whether altered cortisol excretion is present in essential hypertension.
  • To establish reference ranges for urinary cortisol measurements in normotensive individuals.

Main Methods:

  • Measured 24-hour urinary free cortisol and cortisol to creatinine ratios over 14 days in early morning urine samples.
  • Established reference ranges in 26 normotensive subjects.
  • Compared measurements between 9 normotensive and 9 essential hypertensive subjects matched for age, sex, and BMI.

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Main Results:

  • Established reference range for urinary free cortisol: 240 +/- 13 nmol/l and cortisol to creatinine ratio: 22 +/- 1 in normotensive subjects.
  • In hypertensive subjects, urinary free cortisol was 238 +/- 48 nmol/l and cortisol to creatinine ratio was 20 +/- 3.
  • No statistically significant difference was observed in cortisol excretion parameters between the groups.

Conclusions:

  • The study did not demonstrate any abnormality of cortisol excretion in patients with essential hypertension.
  • Cortisol excretion patterns do not appear to be a distinguishing factor in essential hypertension based on this research.