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Related Concept Videos

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Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Related Experiment Video

Updated: Jun 22, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

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Sex-dependent differences in left ventricular function and structure in chronic pressure overload

B Villari1, S E Campbell, J Schneider

  • 1Department of Internal Medicine, University Hospital, Zurich, Switzerland.

European Heart Journal
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Males with aortic stenosis exhibit poorer systolic function and altered myocardial stiffness compared to females. Differences in collagen architecture may explain these observed gender-related variations in heart function.

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Last Updated: Jun 22, 2026

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Cardiac Pathology

Background:

  • Aortic stenosis (AS) is a significant valvular heart disease.
  • Gender-related differences in cardiovascular structure and function are increasingly recognized.
  • The impact of gender on left ventricular (LV) remodeling and function in AS requires further elucidation.

Purpose of the Study:

  • To investigate gender-specific differences in left ventricular (LV) structure and function in patients with aortic stenosis.
  • To explore the relationship between myocardial collagen architecture and observed functional differences between males and females with AS.

Main Methods:

  • LV biplane cineangiography, micromanometry, and endomyocardial biopsies were performed in 56 AS patients and 16 controls.
  • LV systolic and diastolic function were assessed using ejection fraction, wall stress, and pressure decay.
  • Biopsy samples were analyzed for interstitial fibrosis, myofibril volume, and collagen fiber architecture (cross-hatching).

Main Results:

  • Males with AS had larger LV volumes and lower ejection fraction compared to females.
  • Males demonstrated depressed systolic contractility and higher myocardial stiffness.
  • Abnormal collagen architecture, including endocardial fibrosis and increased cross-hatching, was more prevalent in males with AS.

Conclusions:

  • Males with aortic stenosis exhibit impaired systolic function and altered diastolic properties compared to females with similar disease severity.
  • Differences in myocardial collagen architecture likely contribute to the observed gender-based disparities in LV function in AS.
  • These findings highlight the importance of considering gender in the assessment and management of aortic stenosis.