Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Learning-related changes in hippocampal field potentials

E I Moser1

  • 1Centre for Neuroscience, University of Edinburgh, UK.

Behavioural Brain Research
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal granule cells opt for early retirement.

Hippocampus·2010
Same author

What is the mammalian dentate gyrus good for?

Neuroscience·2008
Same author

A test of the reverberatory activity hypothesis for hippocampal 'place' cells.

Neuroscience·2005
Same author

Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2003
Same author

New excitement in cognitive space: between place cells and spatial memory.

Current opinion in neurobiology·2001
Same author

Impaired recognition of the goal location during spatial navigation in rats with hippocampal lesions.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same journal

Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms.

Behavioural brain research·2026
Same journal

Hippocampal plasticity predicts behavioral lateralization and stress resilience in laying hen chicks.

Behavioural brain research·2026
Same journal

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.

Behavioural brain research·2026
Same journal

Bacopa-Enriched Formulation Enhances Memory and Synaptic Plasticity in a Rat Model of Vascular Dementia.

Behavioural brain research·2026
Same journal

Prior exposure to methylphenidate attenuates ethanol-induced conditioned place preference in zebrafish.

Behavioural brain research·2026
Same journal

Plasma nectin-4 levels are associated with changes in executive function in patients with methamphetamine use disorder undergoing treatment.

Behavioural brain research·2026
See all related articles

Brain temperature significantly influences hippocampal field potentials during learning tasks. While temperature changes affect synaptic transmission, spatial learning efficiency remains unaffected, suggesting distinct mechanisms for memory formation.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Synaptic Plasticity

Background:

  • Learning is traditionally linked to synaptic strength modifications.
  • Long-term potentiation (LTP) in the hippocampus is often correlated with learning, but this link may be indirect.
  • Direct recording of cellular activity during learning tasks is crucial for understanding memory mechanisms.

Purpose of the Study:

  • To investigate the influence of non-learning factors, specifically brain temperature, on hippocampal field potentials during learning.
  • To differentiate temperature-induced synaptic changes from true learning-related synaptic potentiation.
  • To assess the impact of temperature variations on spatial learning efficiency.

Main Methods:

  • Field potential recordings in the hippocampus during learning tasks.

Related Experiment Videos

  • Manipulating brain temperature to observe its effect on field potentials and synaptic transmission.
  • Analyzing water-maze tasks to evaluate spatial learning efficiency at different temperatures.
  • Subtracting temperature-related components from field potential data during exploration tasks.

    • Main Results:

    • Hippocampal field potentials are highly sensitive to brain temperature fluctuations.
    • A significant portion of increased field excitatory postsynaptic potentials (f-EPSPs) during learning is attributable to brain warming.
    • Spatial learning in a water-maze task is not impaired by altered brain temperatures (30-39°C).
    • Exploration tasks reveal a temperature-independent synaptic potentiation, evidenced by increased f-EPSPs and population spikes that decay over 15-20 minutes.

    Conclusions:

    • Brain temperature is a critical confound in interpreting hippocampal field potentials as direct indicators of learning-related synaptic changes.
    • Synaptic potentiation observed during learning tasks may involve both temperature-dependent and independent components.
    • Further research is needed to determine the precise role and utility of this temperature-independent potentiation in cognitive processes.