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Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined
A Farrell1, L Scerri, A Stevens
1Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
Pediatric Dermatology
|December 1, 1995
Abstract:
We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft-versus-host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.