Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methods of stem cell mobilization

A Dasgupta1, D M Willerford, S L McAfee

  • 1Division of Hematology Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

The Journal of Infusional Chemotherapy
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2022
Same author

Search for a heavy vector resonance decaying to a <math></math>  boson and a Higgs boson in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Precision luminosity measurement in proton-proton collisions at <math> </math> in 2015 and 2016 at CMS.

The European physical journal. C, Particles and fields·2021
Same author

Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

MUSiC: a model-unspecific search for new physics in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021

Peripheral blood stem cell (PBSC) transplantation rapidly restores blood cell production. Improved PBSC mobilization using growth factors and chemotherapy enhances progenitor collection and speeds recovery after high-dose chemotherapy.

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Transplantation

Background:

  • High-dose chemotherapy regimens are increasingly used for malignancies.
  • Rapid hematopoietic recovery post-transplantation is crucial for patient outcomes.
  • Peripheral blood stem cells (PBSC) are a key component in modern transplantation.

Purpose of the Study:

  • To review current methods for enhancing PBSC mobilization and collection.
  • To discuss the role of hematopoietic growth factors and chemotherapy in PBSC mobilization.
  • To explore novel strategies for improving PBSC collection efficiency and engraftment.

Main Methods:

  • Review of existing literature on PBSC mobilization strategies.
  • Analysis of approaches combining chemotherapy with hematopoietic growth factors.

Related Experiment Videos

  • Discussion of emerging techniques including novel cytokine combinations and in vitro expansion.

    • Main Results:

    • PBSC mobilization regimens enhance circulating hematopoietic progenitors.
    • Combined chemotherapy and growth factor use can increase progenitor yield.
    • Optimized collection reduces the need for multiple leukapheresis procedures.

    Conclusions:

    • Effective PBSC mobilization is vital for successful high-dose chemotherapy.
    • Current strategies significantly improve stem cell collection efficiency.
    • Future research into novel cytokines and in vitro expansion holds promise for further advancements.