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Genealogies and geography

N H Barton1, I Wilson

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|July 29, 1995
PubMed
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Understanding gene genealogies in structured populations is key. Most gene pairs are distantly related, with only a few providing insights into current gene flow, complicating population genetic analysis.

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Spatial genetics

Background:

  • Genes share a common ancestor, with individual properties like sequence and location.
  • Sexual reproduction creates complex, multi-locus genealogies complicating population genetic analysis.
  • Gene genealogies are closely related to identity by descent in spatially structured populations.

Purpose of the Study:

  • To review the relationship between genealogy distribution and identity by descent theory.
  • To develop a diffusion approximation for coalescence times in 2D populations.
  • To assess the utility of spatial dispersion as an estimator of gene flow.

Main Methods:

  • Review of identity by descent theory in structured populations.
  • Development of a diffusion approximation for coalescence times.

Related Experiment Videos

  • Analysis of gene pair relatedness in relation to neighborhood size.
  • Main Results:

    • A small fraction of gene pairs are closely related in large populations, informing current gene flow.
    • Spatial dispersion increase with lineage age is an unreliable estimator of gene flow.
    • The majority of genealogical information reflects long-term population history.

    Conclusions:

    • Gene flow is best inferred from closely related gene pairs, not overall spatial dispersion.
    • Long-term population history is encoded in the bulk of gene genealogies.
    • Concordance of genealogies across loci can reveal past population dynamics.