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Related Experiment Videos

Keloid and hypertrophic scars: trace element alteration

R L Bang1, H Dashti

  • 1Al-Babtain Center for Plastic Surgery and Burns, Faculty of Medicine, Kuwait University, Kuwait.

Nutrition (Burbank, Los Angeles County, Calif.)
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

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This study investigated trace elements in keloid and hypertrophic scars. While manganese levels increased in scar tissue, no definitive link was found between these elements and scar formation.

Area of Science:

  • Dermatology
  • Biochemistry
  • Wound Healing Research

Background:

  • Excessive fibroblastic proliferation causes hypertrophic and keloid scars.
  • Trace elements like zinc are crucial for wound healing.
  • Abnormal trace element levels are observed in various disease states.

Purpose of the Study:

  • To assess serum and skin levels of zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) in patients with keloid and hypertrophic scars.
  • To determine if alterations in these trace elements correlate with scar development.

Main Methods:

  • Serum, normal skin, and scar tissue samples were collected from 40 patients with keloid and hypertrophic scars.
  • Levels of Zn, Cu, Mn, and Se were measured in these samples.
  • Statistical analysis was performed to compare trace element levels between patient groups and controls.

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Main Results:

  • Manganese (Mn) levels were significantly elevated in the skin of patients with burn, trauma, and surgical incisions compared to controls (p < 0.0013, p < 0.0001, p < 0.046, respectively).
  • Zinc (Zn), copper (Cu), and selenium (Se) levels in the skin of incision patients were significantly decreased compared to other groups.
  • No significant differences in serum levels of Zn, Cu, Mn, and Se were observed across the different groups.

Conclusions:

  • The study found no direct relationship between the assessed trace elements and the formation of hypertrophic and keloid scars.
  • Further research with larger patient cohorts is needed to draw definitive conclusions due to the limited sample size.