Characterization of polymorphic forms of fluconazole using Fourier transform Raman spectroscopy

Detailed Fourier transform Raman spectra of fluconazole have been recorded and the main spectral features of fluconazole have been assigned to its vibrational modes. Two different polymorphic forms of fluoconazole were identified in two spectral regions, 150-1700 cm-1 and 2700-3200 cm-1, respectively. The FT-Raman results agree well with those of differential scanning calorimetry and X-ray powder diffractometry. The combination of definiteness with easy sample handling makes FT-Raman spectroscopy a valuable technique for the analysis of polymorphs.