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Related Experiment Videos

A novel dextran 40-based preservation solution

D Candinas1, F Largiadèr, U Binswanger

  • 1Department of Surgery, University of Zurich Hospital, Switzerland.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1996
PubMed
Summary
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Dextran 40 can replace hydroxyethylstarch in kidney preservation solutions, offering comparable results to the standard University of Wisconsin solution. This finding supports its use in clinical kidney transplantation, especially for marginal donors.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Organ Preservation

Background:

  • The University of Wisconsin (UW) solution is the standard for kidney preservation.
  • The role of hydroxyethylstarch (HES) in UW solution has been questioned.
  • Colloids like HES may benefit multiorgan procurements and marginal donor organs.

Purpose of the Study:

  • To evaluate a dextran 40-based preservation solution (Dex-PS) for human kidney grafts.
  • To compare transplantation outcomes of Dex-PS with the UW solution.
  • To assess the efficacy of dextran 40 as a HES substitute in kidney preservation.

Main Methods:

  • A clinical study comparing Dex-PS and UW solution for kidney preservation.
  • Matched cohort of 87 kidneys preserved with Dex-PS and 87 with UW solution.

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  • Inclusion of kidneys from nonheart-beating donors in both groups.

    • Main Results:

    • Comparable patient survival (95% Dex-PS vs. 94% UW) and graft survival (86% Dex-PS vs. 90% UW) at 1 year (P=NS).
    • No significant differences in primary nonfunction, delayed graft function, or postoperative dialysis needs.
    • Statistically similar serum creatinine levels during follow-up between groups.

    Conclusions:

    • Dextran 40 is a safe and effective substitute for HES in clinical kidney preservation solutions.
    • Dex-PS demonstrates comparable efficacy to UW solution for kidney transplantation.
    • No statistically detectable differences in graft performance were observed.