MR measurement of time-dependent blood pressure variations

An MR imaging method for measuring intravascular pressure variations is introduced. The technique is based on estimates of vascular compliance and vessel distension, which are obtained from a correlation of spatial and temporal velocity derivatives and measurements of the velocity gradient in the direction of flow, respectively. The accuracy of the technique was determined in vitro through a comparison of MR and transducer pressure measurements obtained in distensible vessel phantoms undergoing pulsatile flow. Results indicated that a root-mean-square error of 4-12% can be expected in phantoms covering a physiological range of compliance. In vivo feasibility was demonstrated by thoracic aorta pressure measurements, which produced pressure waveforms with an expected shape and magnitude.