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Stressors, including social conflict, decrease plasma prolactin in male golden hamsters
K L Huhman1, E H Mougey, T O Moore
1Department of Biology and Psychology, Georgia State University, Atlanta 30303, USA.
Hormones and Behavior
|December 1, 1995
Summary
Stressful situations unexpectedly lowered plasma prolactin (PRL) in subordinate hamsters, unlike other stress hormones. This study investigated PRL response to social conflict and footshock stress in male Syrian hamsters.
Area of Science:
- Neuroendocrinology
- Behavioral Neuroscience
- Stress Physiology
Background:
- Plasma prolactin (PRL) typically increases after stress exposure across species.
- Understanding stress-induced hormonal changes is crucial for physiological research.
Purpose of the Study:
- To investigate the impact of social conflict and footshock stress on PRL levels in male Syrian hamsters.
- To compare PRL response in dominant versus subordinate hamsters during social conflict.
Main Methods:
- Male Syrian hamsters were exposed to social conflict or mild footshock stress.
- Plasma PRL and adrenocorticotropin levels were measured after repeated stressor exposures.
- Dopamine's role in PRL regulation was assessed using domperidone, a dopamine receptor blocker.
Main Results:
- Subordinate hamsters exhibited significantly lower PRL levels compared to dominant or control hamsters after social conflict.
- Mild footshock stress also led to reduced PRL levels in hamsters.
- Adrenocorticotropin levels increased in response to both stressors.
- Dopamine receptor blockade with domperidone dose-dependently increased PRL release, confirming dopamine's inhibitory effect.
Conclusions:
- Contrary to typical stress responses, social subordination and mild footshock reduce PRL levels in male Syrian hamsters.
- These findings highlight a species- and context-specific modulation of the PRL stress response.
- Dopamine plays a significant inhibitory role in regulating PRL release in hamsters, consistent with other species.