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Related Experiment Videos

Tenascin distribution in human brain tumours

P Castellani1, A Dorcaratto, A Siri

  • 1Department of Neurosurgery, University of Genoa Medical School, Italy.

Acta Neurochirurgica
|January 1, 1995
PubMed
Summary

Tenascin (TN) is a stromal marker, not a tumor marker, in intracranial growths. Its varied distribution in gliomas may affect treatment response to anti-TN antibodies.

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Area of Science:

  • Neuro-oncology
  • Immunohistochemistry
  • Cancer Biology

Background:

  • Tenascin (TN) is an extracellular matrix glycoprotein implicated in various cellular processes.
  • Its role as a specific marker for malignant tumors versus stromal component is not fully elucidated.

Purpose of the Study:

  • To investigate the expression patterns of tenascin (TN) in various intracranial growths using immunohistochemistry.
  • To determine if TN serves as a marker for neoplastic cells or the tumor stroma.

Main Methods:

  • Immunohistochemical analysis of 180 intracranial growths.
  • Utilized a monoclonal antibody specific for human tenascin (TN).
  • Evaluated TN reactivity in neoplastic cells and stromal components across different tumor types.

Main Results:

  • Tenascin (TN) was predominantly found in the stroma of all intracranial growths studied, including meningiomas, gliomas, metastases, abscesses, and tuberculomas.
  • Neoplastic cells in meningiomas were largely negative for TN, with stromal positivity noted.
  • Gliomas showed variable TN reactivity in both cellular and stromal components, with higher heterogeneity in anaplastic astrocytomas and glioblastomas.

Conclusions:

  • The findings support the hypothesis that tenascin (TN) functions as a stromal marker rather than a direct marker of malignant tumor cells.
  • The heterogeneous distribution of TN in anaplastic gliomas could influence the efficacy of treatments using radiolabeled anti-TN monoclonal antibodies.

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