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Related Experiment Videos

Stable prostacyclin improves postischaemic microcirculatory changes in hypertensive rats

K Shima1, H Umezawa, H Chigasaki

  • 1Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan.

Acta Neurochirurgica
|January 1, 1995
PubMed
Summary

The prostacyclin analogue TTC-909 improved cerebral blood flow and reduced blood-brain barrier damage in rats after stroke. This treatment helps maintain blood supply and prevent brain swelling following ischemic events.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Cardiovascular Research

Background:

  • Focal cerebral ischemia leads to microcirculatory dysfunction, blood-brain barrier disruption, and edema.
  • Prostacyclin analogues are investigated for their potential therapeutic effects in ischemic stroke.

Purpose of the Study:

  • To evaluate the efficacy of TTC-909, a stable prostacyclin analogue in lipid microspheres, on cerebral microcirculation after focal cerebral ischemia.
  • To assess the impact of TTC-909 on regional cerebral blood flow, blood-brain barrier permeability, and brain edema.

Main Methods:

  • Focal cerebral ischemia was induced by middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats.
  • TTC-909 was administered intravenously for 7 days, starting 30 minutes post-occlusion.

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  • Cerebral blood flow, blood-brain barrier permeability, brain edema, and infarct size were quantified on day 7.

    • Main Results:

    • TTC-909 treatment significantly improved regional blood flow in the ischemic rim and surrounding areas.
    • The drug significantly reduced blood-brain barrier permeability in the ischemic center and rim.
    • TTC-909 prevented the decrease in specific gravity in both ischemic and remote non-ischemic regions, indicating prevention of edema.

    Conclusions:

    • TTC-909 demonstrates significant therapeutic efficacy in a rat model of focal cerebral ischemia.
    • The drug's benefits are attributed to maintaining blood supply, improving blood-brain barrier integrity, and preventing ischemic edema.
    • TTC-909 holds promise for treating ischemic stroke by mitigating key pathological consequences.