Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carmofur-induced leukoencephalopathy: MRI

S Matsumoto1, S Nishizawa, M Murakami

  • 1Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.

Neuroradiology
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical characteristics and outcomes of pheochromocytoma crisis: a literature review of 200 cases.

Journal of endocrinological investigation·2022
Same author

Paraneoplastic pemphigus associated with Castleman disease: progression from mucous to mucocutaneous lesions with epitope-spreading phenomena.

The British journal of dermatology·2017
Same author

Preoperative prediction for regaining ambulatory ability in paretic non-ambulatory patients with metastatic spinal cord compression.

Spinal cord·2016
Same author

Paracoccidioides brasiliensis and P. lutzii antigens elicit different serum IgG responses in chronic paracoccidioidomycosis.

Mycopathologia·2013
Same author

Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats.

Neuroscience·2013
Same author

Epithelial to mesenchymal transition in murine tracheal allotransplantation: an immunohistochemical observation.

Transplantation proceedings·2013

Carmofur, a 5-fluorouracil derivative, can cause rare leukoencephalopathy. Early MRI shows diffuse white matter changes, aiding diagnosis.

Area of Science:

  • Neuroimaging
  • Oncology
  • Pharmacology

Background:

  • Carmofur, a 5-fluorouracil derivative, is used in cancer therapy.
  • Leukoencephalopathy is an infrequent but serious adverse effect of carmofur.
  • Early magnetic resonance imaging (MRI) findings in carmofur-induced leukoencephalopathy are not well-documented.

Observation:

  • This report details a case of carmofur-induced leukoencephalopathy.
  • The patient presented with diffuse high signal intensity in the cerebral white matter on T2-weighted MRI.
  • These changes included the corpus callosum, indicating widespread white matter involvement.

Findings:

  • The MRI findings, while not pathognomonic, are characteristic of white matter disease.
  • Diffuse cerebral white matter hyperintensities on T2-weighted MRI were observed.

Related Experiment Videos

  • The corpus callosum was notably affected, suggesting extensive demyelination or edema.

    • Implications:

    • Carmofur-induced leukoencephalopathy should be considered in patients on carmofur therapy presenting with neurological symptoms.
    • Early recognition of these MRI findings is crucial for prompt diagnosis.
    • Understanding the clinical and imaging characteristics can improve patient prognosis through timely intervention.