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Seizures associated with ofloxacin therapy
S M Traeger1, M F Bonfiglio, J A Wilson
1Department of Internal Medicine, Critical Care Service, SUMMA Health System/Akron City Hospital, Akron, Ohio, USA.
Summary
Older patients on high-dose ofloxacin experienced seizures, possibly due to drug accumulation, especially with kidney issues. Further research into ofloxacin
Area of Science:
- Pharmacology
- Neurology
- Clinical Medicine
Background:
- Ofloxacin is a fluoroquinolone antibiotic used for various bacterial infections.
- Seizures are a known, though rare, adverse effect of some antibiotics.
Observation:
- Four elderly patients developed seizures while undergoing treatment with ofloxacin.
- No other potential causes for the seizures were identified in these patients.
Findings:
- Advanced age and high-dose ofloxacin regimens were common factors in the observed cases.
- Renal insufficiency in three patients suggested ofloxacin accumulation as a contributing factor to seizures.
- Electrolyte imbalances and previous neurological damage were also considered potential related factors.
Implications:
- Increased clinical awareness of ofloxacin-induced neurotoxicity is warranted.
- Further investigation into the mechanisms of ofloxacin neurotoxicity may improve patient safety.
- This highlights the need for careful patient selection and monitoring when prescribing ofloxacin, particularly in vulnerable populations.