Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isoxazole anthelmintics

J B Carr, H G Durham, D K Hass

    Journal of Medicinal Chemistry
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    New isoxazole compounds show promise as anthelmintics against the rat roundworm, Nippostrongylus braziliensis. Structure-activity relationships reveal distinct requirements for efficacy in different compound series.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Scaphoid Waist Nonunion in an 8-Year-Old: A Rare Occurrence.

    Case reports in orthopedics·2019
    Same author

    A change as remarkable "as the Revolution itself": Boston's demographics, 1780-1800.

    The New England quarterly·2007
    Same author

    The literature on calcaneal fractures is highly controversial.

    Foot & ankle international·2001
    Same author

    An unusual case of vascular dysplasia related to knee arthroscopy.

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2001
    Same author

    Dorsiflexion metatarsal osteotomy for treatment of recalcitrant diabetic neuropathic ulcers.

    Foot & ankle international·2000
    Same author

    Unexpected hip arthrogram during cystography in a patient with extraperitoneal bladder rupture and acetabular fracture.

    AJR. American journal of roentgenology·1999
    Same journal

    Library Docking for Cannabinoid-2 Receptor Ligands.

    Journal of medicinal chemistry·2026
    Same journal

    Charting New Territory: Systematic Evaluation of the Drug Potential of <i>N</i>-Trifluoromethyl Amides, Ureas & Carbamates.

    Journal of medicinal chemistry·2026
    Same journal

    Red-Light-Triggered <i>In Vitro</i> and <i>In Vivo</i> Photocatalytic Cancer Therapy with Polypyridyl Os(II) Photocatalysts.

    Journal of medicinal chemistry·2026
    Same journal

    Novel Selenium-Containing Small Molecule PD-L1 Inhibitors: Design, Synthesis, and Evaluation of the Antitumor Activity.

    Journal of medicinal chemistry·2026
    Same journal

    HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy.

    Journal of medicinal chemistry·2026
    Same journal

    Rational Development of Activatable Prodrugs of the GSTP1 Inhibitor NBDHEX: Turn-On NIR Fluorogenic Drug Delivery with Selective Anticancer Activity.

    Journal of medicinal chemistry·2026
    See all related articles

    Area of Science:

    • Medicinal Chemistry
    • Parasitology
    • Organic Synthesis

    Background:

    • Anthelmintic resistance necessitates the development of novel therapeutic agents.
    • Isoxazole derivatives are a class of heterocyclic compounds with diverse biological activities.

    Purpose of the Study:

    • To synthesize and evaluate the anthelmintic activity of novel 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazole derivatives.
    • To investigate the structure-activity relationships (SAR) of these isoxazole compounds against Nippostrongylus braziliensis.

    Main Methods:

    • Synthesis of a series of 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles.
    • Oral administration of synthesized compounds to rats infected with Nippostrongylus braziliensis.
    • Evaluation of anthelmintic activity based on worm burden reduction.

    Related Experiment Videos

    Main Results:

    • Several 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles exhibited significant anthelmintic activity at doses of 16-500 mg/kg.
    • A halogen at the 3-position was crucial for activity in the 5-phenyl series.
    • In the 3-phenyl series, activity persisted with alkoxyl, thioalkoxyl, or amino substitutions at the 5-position.
    • Evidence suggests distinct biological receptor sites for the 3-phenyl and 5-phenyl isoxazole series.

    Conclusions:

    • The synthesized isoxazole derivatives represent a promising scaffold for developing new anthelmintic drugs.
    • SAR studies indicate opportunities for optimizing isoxazole-based anthelmintics with varied substitution patterns.
    • The findings suggest potential for developing targeted anthelmintic therapies based on specific isoxazole structural motifs.