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Correlation of ultrasound bone velocity with dual-energy X-ray bone absorptiometry in rat bone specimens
C Amo1, M Revilla, E R Hernandez
1Department of Medicine, Universidad de Alcala de Henares, Madrid, Spain.
Rationale And Objectives:
To investigate bone mass measurements by ultrasound bond velocity (UBV) in bone specimens obtained from experimental animals.
Methods:
The authors made UBV measurements in 40 femurs and tibias dissected from Sprague-Dawley rats (14 weeks-old, mean weight 290 g) and compared them with bone densitometric measurements made on the same material using dual-energy x-ray absorptiometry (DXA).
Results:
The coefficient of variation for UBV measurements, based on values obtained in five femurs and five tibias at different times, was 0.2% and 0.3% respectively. Regression studies yielded a correlation between UBV and bone mineral density in femur of r = 0.87 (P < 0.0001) and with bone mineral content of r = 0.65 (P < 0.0001); in the tibia similar levels of significance were obtained. The correlation between femur weight and UBV was r = 0.51 (P < 0.0005) and with bone mineral content it was r = 0.79 (P < 0.0001). Partial correlation between UBV and femur bone mineral density, with respect to bone weight, was r = 0.68 (P < 0.001), and with femur bone mineral content was r = 0.71 (P < 0.0001). In the tibia measurements were similarly significant.
Conclusions:
Measurements of bone mass made with ultrasound transmission velocity are precise correlate well with DXA measurements.