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Simian varicella virus antibody response in experimental infection of African green monkeys
W L Gray1, N J Gusick, T M Fletcher
1Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, USA.
Abstract:
The humoral immune response to simian varicella virus (SVV) was investigated following primary and secondary experimental infection of African green monkeys. Neutralization and immunoprecipitation assays were used to determine antibody titers to SVV throughout the course of infection. The immune response to specific viral polypeptides was analyzed by immunoprecipitation analysis. The results demonstrate that the simian varicella model offers a useful approach to investigate immune mechanisms in human varicella zoster virus (VZV) infections.
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