Related Experiment Videos
[Adverse reactions to different types of influenza vaccines]
M Bernad Valles1, J C Núñez Mateos, O Castillo Soria
1Unidad Docente de Medicina Familiar y Comunitaria, Gerencia de Atención Primaria de Avila, INSALUD.
Background:
The objective was to establish the rate of adverse reactions to the various influenza vaccines (whole, fractionated and subunits).
Methods:
The prescription and the adverse reactions to 21,391 influenza vaccinations carried out in the Avila province, Spain, were studied using a questionnaire filled in at the moment when the vaccine was administered and one or two weeks afterwards. The statistical tests used were the residual chi 2 and the multivariate logistic regression analysis.
Results:
Adverse reactions were observed in 28.8% of the cases. Local pain (18.8%) and redness (13.4%) were the most frequent reactions. 3% of the vaccinated people had fever, 4.9% general malaise and 1.2% were confined in bed. Other adverse reactions were observed in 5.4% of the persons. The differences between the various vaccines were significant (whole vaccines with a rank, according to the trademark, 27.7% to 35.8%; fractionated, 27.3% and subunits, 24.4%).
Conclusions:
Inactivated whole and fractionated vaccines cause more adverse reactions, mainly local, than subunit vaccines. There are no differences in adverse sistemic reactions. Occupational prescription and vaccines administered to persons older than 65 were the lowest risk prescriptions.