The subsensitivity of striatal glutamate receptors induced by chronic haloperidol in rats

The aim of the present study was to investigate the influence of chronic treatment with haloperidol on the contralateral head turns and rotations induced by intrastriatal agonists of NMDA and non-NMDA receptors in rats. N-Methyl-D-aspartate (NMDA, 500 ng/0.5 mu l), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 mu l) or kainic acid (50 ng/0.5 mu l), injected into the intermediate and caudal parts of the caudate-putamen, induced contralateral head turns and rotations. Haloperidol was given to animals in a dose of ca. 1 mg/kg per day in drinking water for 6 weeks. On day 5 of withdrawal, haloperidol decreased the number of contralateral head turns, but did not significantly influence the contralateral rotations induced by NMDA, AMPA and kainic acid. At the same time, haloperidol enhanced the stereotypy induced by apomorphine (0.25 mg/kg s.c.). The present results seem to suggest that, apart from supersensitivity to dopamine, chronic treatment with haloperidol also induces subsensitivity of striatal NMDA and non-NMDA receptors.