Related Experiment Video
Updated: Aug 23, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
The use of tissue plasminogen activator in post-traumatic total hyphaema
1Department of Opthalmology, Oulu University Hospital, Finland.
Background:
We wanted to evaluate whether intracameral injection of tissue plasminogen activator (tPA) is useful in managing traumatic hyphaema.
Methods:
Two eyes with total hyphaema after a severe penetrating injury were treated with a single intracameral injection of 25 micrograms of tPA 5 and 14 days after the injury, respectively.
Results:
Most of the blood coagulum dissolved within 24 h, and in one of the two eyes the intraocular pressure decreased from 45 to 8 mmHg. The other eye was hypotonic. No re-bleeding or complications related to the use of tPA were noticed.
Conclusion:
The results in these two cases suggest that tPA is a useful adjunct in managing total hyphaema.
Related Concept Videos
Clot Retraction and Fibrinolysis
Venous Thrombosis III: Interprofessional Care
Hemorrhagic Stroke ll: Pathophysiology

