Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eye movement in amyotrophic lateral sclerosis: a longitudinal study

A Palmowski1, W H Jost, J Prudlo

  • 1Augenklinik und Poliklinik, Universität des Saarlandes, Homburg/Saar, Germany.

German Journal of Ophthalmology
|November 1, 1995
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) may affect eye muscles earlier than previously thought. Electro-oculography (EOG) shows subclinical eye movement impairment in most ALS patients, aiding early detection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuromyelitis optica spectrum disorder coinciding with hematological immune disease: A case report.

Multiple sclerosis and related disorders·2016
Same author

Big-endothelin in acute ischemic stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Is cardiovascular dysregulation in idiopathic Parkinson's syndrome correlated with decreased hormonal release?; TO THE EDITOR.

European journal of neurology·2013
Same author

[Femtosecond laser ablation and scanning microscopy of the internal retinal limiting membrane: an experimental study].

Vestnik oftalmologii·2009
Same author

[TDP-43 proteinopathies: ALS and frontotemporal dementias].

Fortschritte der Neurologie-Psychiatrie·2009
Same author

An association of migraine with hereditary haemorrhagic telangiectasia independently of pulmonary right-to-left shunts.

Cephalalgia : an international journal of headache·2008

Area of Science:

  • Neurology
  • Ophthalmology
  • Neurodegenerative Diseases

Background:

  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder.
  • Previously, eye and sphincter muscles were considered spared in ALS.
  • Recent findings suggest subclinical anal sphincter impairment in ALS.

Purpose of the Study:

  • To investigate earlier and more frequent oculomotor system involvement in ALS than previously described.
  • To assess subclinical ocular movement impairment in ALS patients.

Main Methods:

  • Studied oculomotor involvement in eight ALS patients from 1993 onwards.
  • Utilized routine orthoptic examination and electro-oculography (EOG) for ocular movement recording.
  • Compared clinical findings with EOG results.

Related Experiment Videos

Main Results:

  • Three patients had normal clinical exams but progressive EOG changes.
  • Three patients showed intermittent eye movement impairment with varied EOG results.
  • Two patients exhibited progressively abnormal clinical exams and EOG.
  • EOG changes were detectable in all but one patient, suggesting subclinical impairment.

Conclusions:

  • Findings support early oculomotor involvement in ALS, potentially preceding respiratory failure.
  • Electro-oculography (EOG) may enable earlier, subclinical detection of eye movement impairment in ALS.
  • Further research with larger patient cohorts and advanced software is needed to confirm oculomotor involvement frequency and patterns in ALS.