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Merkel cell carcinoma: CT findings in 12 patients
M J Gollub1, D R Gruen, D D Dershaw
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
AJR. American Journal of Roentgenology
|September 1, 1996
Summary
Computed tomography (CT) effectively identifies Merkel cell carcinoma (MCC) by revealing primary skin lesions and metastases in lymph nodes and organs. This imaging technique aids in the crucial staging of this rare skin cancer.
Area of Science:
- Oncology
- Radiology
- Dermatology
Background:
- Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer.
- Accurate staging is critical for effective treatment planning and prognosis.
Purpose of the Study:
- To characterize the computed tomography (CT) imaging features of Merkel cell carcinoma.
- To evaluate the utility of CT in identifying primary lesions and metastatic spread.
Main Methods:
- Retrospective review of 53 CT scans from 12 patients with biopsy-proven MCC.
- Analysis of primary tumor characteristics (size, location, attenuation) and metastatic sites (lymph nodes, visceral organs, subcutaneous tissue).
Main Results:
- Primary MCC lesions appeared as hyper- or isodense cutaneous nodules on CT.
- Metastases were commonly found in regional and distant lymph nodes, liver, and subcutaneous fat.
- Other metastatic sites included the mediastinum, peritoneum, adrenal gland, and lung. Nodal and subcutaneous metastases were typically hyperdense, often with associated linear stranding.
Conclusions:
- CT imaging provides valuable insights into the presentation and extent of Merkel cell carcinoma.
- CT is a useful tool for the accurate staging of Merkel cell carcinoma, guiding clinical management.