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Pregnancy rates after communal growth of preimplantation human embryos in vitro
1Department of Obstetrics and Gynecology, Bikur Cholim Hospital, Jerusalem, Israel.
Objective:
To evaluate the effect of communal growth of preimplantation human embryos on pregnancy rates in IVF-ET.
Design:
Prospective randomized study.
Setting:
In Vitro Fertilization Unit, Bikur Cholim Hospital, Jerusalem, Israel.
Patients:
Ninety-one women undergoing 91 cycles of IVF-ET.
Intervention:
In 42 cycles (control) embryos were grown singly, in 49 cycles (study) embryos were grown in groups until transfer.
Main Outcome Measures:
Proportion of women achieving pregnancy in study and control groups.
Results:
Communal growth of embryos resulted in significantly improved pregnancy rates. Intrauterine transfer of embryos grown in groups produced 43% pregnancy rates per transfer, whereas, with embryos grown individually, 24% pregnancy rates were obtained (odds ratio = 2.4).
Conclusions:
Our study suggests that, in IVF, the potential of preimplantation human embryos to produce pregnancy tends to increase when embryos are grown in groups.