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Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2
M P Conte1, C Longhi, M Polidoro
1Institute of Microbiology, University of Rome La Sapienza, Italy.
Infection and Immunity
|September 1, 1996
Abstract:
The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.