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Updated: Aug 17, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
L B Zimmerman1, J M De Jesús-Escobar, R M Harland
1Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720, USA.
Abstract:
Signals released by the Spemann organizer of the amphibian gastrula can directly induce neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the organizer signal. Neural induction and mesoderm dorsalization are antagonized by bone morphogenetic proteins (BMPs), which induce epidermis and ventral mesoderm instead. Here we report that noggin protein binds BMP4 with high affinity and can abolish BMP4 activity by blocking binding to cognate cell-surface receptors. These data suggest that noggin secreted by the organizer patterns the embryo by interrupting BMP signaling.
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