Management of patients in shock

Clinical study was conducted in the course of treatment of patients with hypovolemic and septic shock at Department of Traumatology, Osaka University Hospital. We have found large difference between data obtained in our study and experimental results obtained in animals. In hypovolemic shock of man, we could not observe "taking up phenomenon" to abdominal organs. Therefore, if the shock does not respond to transfusion and infusion, we must look for other causes. In patients whose shock state persisted more than 10 hours, death related to shock organs increased remarkably. The nature of septic shock in man is hyperdynamic state. Hemodynamic change during the development of septic shock from sepsis was described and the difference from experimental research on endotoxin shock in animals was discussed.