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Risks for transmission of hepatitis C virus during artificial insemination
Objective:
To identify risks of hepatitis C virus transmission by semen from infected donors.
Design:
Case report.
Setting:
Assisted fertility clinic.
Patients:
Hepatitis C virus-infected semen donor and recipients of his donations.
Intervention:
Testing for hepatitis C virus by serology and polymerase chain reaction.
Main Outcome Measures:
Detection of hepatitis C virus antibodies and viral RNA.
Results:
Hepatitis C virus RNA was detected in the semen donation before but not after purification; none of the recipients of the donors samples were found to have antibodies to hepatitis C virus.
Conclusions:
Hepatitis C virus RNA can be detected in semen donations from infected donors; purification of donations before insemination significantly reduces the amount of viral RNA in the semen pellet.
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