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Physiologic changes in the dog anesthetized with thiamylal and enflurane
Laboratory Animal Science
|June 1, 1977
Summary
Enflurane anesthesia in dogs caused minor cardiovascular changes but significantly impacted respiration, leading to increased CO2 and decreased pH. Hematologic parameters and body temperature also dropped during anesthesia.
Area of Science:
- Veterinary Anesthesiology
- Canine Physiology
Background:
- Enflurane is a volatile anesthetic agent.
- Thiamylal is used for anesthetic induction.
Purpose of the Study:
- To evaluate the physiological effects of enflurane anesthesia with thiamylal induction in dogs.
- To assess cardiovascular, respiratory, hematologic, and blood chemistry changes.
Main Methods:
- Dogs were induced with thiamylal and maintained on enflurane anesthesia.
- Physiological parameters including heart rate, blood pressure, respiratory rate, arterial CO2, blood pH, body temperature, packed cell volume, erythrocyte count, leukocyte count, and alkaline phosphatase were monitored.
Main Results:
- Slight, insignificant changes in heart rate and mean systemic blood pressure were observed.
- Significant respiratory depression, increased arterial partial pressure of CO2, and decreased blood pH occurred.
- Body temperature progressively dropped throughout anesthesia.
- Hematologic changes included reduced packed cell volume, erythrocyte, and leukocyte counts.
- Elevated alkaline phosphatase was noted at 24 and 48 hours post-anesthesia.
Conclusions:
- Enflurane anesthesia with thiamylal induction in dogs causes minimal cardiovascular effects but significant respiratory depression and hypothermia.
- Hematologic parameters are notably affected, with a decrease in cell counts.
- Alkaline phosphatase elevation suggests potential liver or bone effects post-anesthesia.