[Protein phosphorylation in the normal nervous system and in Alzheimer's disease]

Protein phosphorylation induced by neurotransmitters, hormones, different growth factors, nerve impulse is involved in the regulation of a wide variety of physiological processes in the nervous system. The data on abnormal phosphorylation/dephosphorylation processes in the brain of patients with Alzheimer's disease are considered. In AD there are a few phosphoproteins with known function, protein kinases, phosphatases that are altered. The own data on the decrease in casein kinase 2 activity, content and altered spectrum of substrate proteins in Alzheimer's disease are presented. Drastic reductions in zinc- and magnesium-stimulated protein tyrosine activities are also recorded. The important role of abnormalities in the phosphorylation/dephosphorylation system in the stimulation of pathological processes in Alzheimer's disease is noted.