Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The use of null mutant mice to study complex learning and memory processes

J M Wehner1, B J Bowers, R Paylor

  • 1Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA.

Behavior Genetics
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Background genotype modulates the effects of γ-PKC on the development of rapid tolerance to ethanol-induced hypothermia.

Addiction biology·2010
Same author

Fmr1 knockout mice are impaired in a leverpress escape/avoidance task.

Genes, brain, and behavior·2006
Same author

Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome.

Genes, brain, and behavior·2005
Same author

Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors.

Neuroscience·2004
Same author

Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning.

Neuroscience·2004
Same author

Expanded characterization of the social interaction abnormalities in mice lacking Dvl1.

Genes, brain, and behavior·2004

Investigating gene function in learning and memory involves creating null mutant mice. This review covers complex learning paradigms, gene-targeting techniques, and the interpretation of behavioral data from these mutants.

Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Complex learning and memory involve multiple neural substrates in mammals.
  • Gene function is often studied using null mutations in mouse models.
  • Gene-targeted homologous recombination is a key technique for creating these mutants.

Purpose of the Study:

  • To review complex learning and memory paradigms.
  • To describe techniques for creating gene null mutant mice.
  • To discuss the interpretation of behavioral data from these mutants.

Main Methods:

  • Review of existing literature on learning paradigms.
  • Description of embryonic stem cell-based gene-targeting techniques.
  • Analysis of studies utilizing null mutant mice in behavioral tests.

Related Experiment Videos

Main Results:

  • Null mutant mice are valuable tools for studying gene function in learning and memory.
  • Hippocampal integrity is crucial for several complex learning paradigms.
  • Behavioral data from null mutants provide insights into neural substrates of cognition.

Conclusions:

  • Null mutant mice are instrumental in dissecting the genetic basis of learning and memory.
  • Careful interpretation is needed due to potential compensatory mechanisms or off-target effects.
  • This approach advances our understanding of the neural substrates underlying complex cognitive functions.