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Implantable artificial lung. Preliminary report

P J Morin, C Gosselin, R Picard

    The Journal of Thoracic and Cardiovascular Surgery
    |July 1, 1977
    PubMed
    Summary
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    This study introduces a novel woven capillary membrane oxygenator, a potential artificial lung for treating chronic respiratory insufficiency. The device demonstrates efficient oxygen and carbon dioxide transfer rates, suggesting its suitability for implantation or external respiratory support.

    Area of Science:

    • Biomedical Engineering
    • Respiratory Physiology

    Background:

    • Chronic respiratory insufficiency necessitates advanced treatment options.
    • Artificial organs and respiratory supplementation are key research areas.
    • Implantable artificial lungs represent a significant therapeutic goal.

    Purpose of the Study:

    • To evaluate the efficiency of a woven capillary membrane oxygenator.
    • To assess its potential as an artificial lung for respiratory support.
    • To determine its suitability for implantation or paracorporeal use.

    Main Methods:

    • Fabrication of woven capillary membrane oxygenator units with varying screen numbers.
    • Testing oxygen transfer rates with blood.
    • Measuring carbon dioxide transfer rates with water.

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  • Analyzing liquid phase pressure drops at specific flow rates.

    • Main Results:

    • Maximum oxygen transfer rate achieved was 48 ml/min/m².
    • Water carbon dioxide transfer rate was 23.1 ml/min/m².
    • Liquid phase pressure drops ranged from 8.5 to 17.6 mm Hg at 1 L/min flow.

    Conclusions:

    • The woven capillary membrane lung functions as an acceptably efficient oxygenator.
    • Its design and performance characteristics support its potential for chest implantation.
    • The device is also suitable for use as a paracorporeal respiratory assistance system.