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CPx-type ATPases: a class of P-type ATPases that pump heavy metals
1Department of Clinical Pharmacology, University of Berne, Switzerland. solioz@ikp.unibe.ch
Trends in Biochemical Sciences
|July 1, 1996
Abstract:
ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.