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Glutathione amide and its perthiol in anaerobic sulfur bacteria
R G Bartsch1, G L Newton, C Sherrill
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA.
Journal of Bacteriology
|August 1, 1996
Abstract:
Chromatium species produced the novel biological thiol glutathione amide, gamma-L-glutamyl-L-cysteinylglycine amide (GASH), when grown photoheterotrophically. GASH was largely converted to the corresponding perthiol during photoautotrophic growth on sulfide, suggesting that GASH may have a function in anaerobic sulfide metabolism. This unprecedented form of glutathione metabolism was probably present in anaerobic ancestors of modern cyanobacteria and purple bacteria.