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Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant
M Yamamoto1, M Nakagawa, N Ichimura
1Department of Pediatrics, Hyogo College of Medicine, Japan.
American Journal of Hematology
|July 1, 1996
Abstract:
A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymphoid-associated antigens (CD10 and CD19) but not myeloid-associated antigens (CD13, CD14, and CD33). These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage.