Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two metabolites from Aspergillus flavipes

A M Clark, C D Hufford, L W Robertson

    Lloydia
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Two new fungal metabolites, N-benzoyl-L-phenylalaninol and asperphenamate, were discovered in Aspergillus flavipes. Their structures were determined using chemical and spectroscopic analysis, expanding knowledge of fungal-derived compounds.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms.

    Stem cell reviews and reports·2017
    Same author

    A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties.

    Lab on a chip·2016
    Same author

    Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption.

    Toxicology reports·2016
    Same author

    Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure.

    Toxicology·2015
    Same author

    How to research the mechanisms of non-pharmacological cardiac interventions.

    International journal of cardiology·2015
    Same author

    Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes.

    Environmental science and pollution research international·2015
    Same journal

    (+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.

    Lloydia·1979
    Same journal

    Inhibition of reverse transcriptase activity by benzophenanthridine alkaloids.

    Lloydia·1979
    Same journal

    Potential anticancer agents IX. Isolation of a new simaroubolide, 6alpha-tigloyloxychaparrinone, from Ailanthus integrifolia ssp. calycina (Simaroubaceae).

    Lloydia·1978
    Same journal

    Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora.

    Lloydia·1978
    Same journal

    Proceedings of the 19th Annual Meeting of the American Society of Pharmacognosy held with the Phytochemical Society of North America, August 14-17, 1978, Oklahoma State University, Stillwater, Oklahoma.

    Lloydia·1978
    Same journal

    Plant anticancer agents. VIII. Constituents of Inga punctata.

    Lloydia·1978
    See all related articles

    Area of Science:

    • Natural Product Chemistry
    • Mycology
    • Organic Chemistry

    Background:

    • Fungal metabolites represent a rich source of novel chemical structures.
    • Aspergillus species are known producers of diverse bioactive compounds.
    • Characterization of new fungal metabolites is crucial for drug discovery and chemical biology.

    Purpose of the Study:

    • To isolate and characterize novel fungal metabolites from Aspergillus flavipes ATCC 11013.
    • To elucidate the chemical structures of the isolated compounds.
    • To contribute to the understanding of secondary metabolism in fungi.

    Main Methods:

    • Isolation of metabolites from fungal culture filtrate and mycelium.
    • Structure elucidation using spectroscopic techniques (e.g., NMR, MS).

    Related Experiment Videos

  • Comparison with authentic samples for compound identification.

    • Main Results:

    • Two novel fungal metabolites were successfully isolated: N-benzoyl-L-phenylalaninol (1a) and asperphenamate (2).
    • N-benzoyl-L-phenylalaninol was identified by direct comparison with a known standard.
    • The structure of asperphenamate was proposed as (S)-N-benzoyl-phenylalanine-(S)-2-benzamido-3-phenyl propyl ester based on comprehensive data.

    Conclusions:

    • The study successfully identified two new fungal metabolites from Aspergillus flavipes.
    • The structural determination of asperphenamate provides new chemical insights.
    • These findings contribute to the catalog of fungal-derived natural products.