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Effect of delayed radiation therapy on local control in breast conservation therapy
A G Meek1, T L Park, T A Weiss
1Department of Radiation Oncology, University Hospital, Stony Brook, NY 11794-7028, USA.
Purpose:
To assess local control when radiation therapy is delayed to complete chemotherapy in breast conservation therapy.
Materials And Methods:
Breast conservation therapy was performed in 310 cases in 297 patients (aged 24-85 years) with stage 0-II breast cancer. Adjuvant chemotherapy was used in 76 cases. The authors analyzed the time between diagnosis and radiation therapy and correlated these findings with local control of disease.
Results:
The time between diagnosis and radiation therapy in the 247 cases treated without chemotherapy-related delay was 2-59 weeks (mean, 8 weeks). The interval in the 63 cases with chemotherapy-related delay was 12-63 weeks (mean, 31 weeks; P < .001). Ten of the 11 cases with an in breast relapse were in the group treated without a delay (P = .57).
Conclusion:
Delaying radiation therapy for chemotherapy does not compromise local control.