Related Experiment Videos
Selective atrophy of type 1 muscle fibers in McArdle's disease
K J Felice1, M L Grunnet, A A Sima
1Department of Neurology, University of Connecticut School of Medicine, Farmington, USA.
Neurology
|August 1, 1996
Abstract:
McArdle's disease is a metabolic myopathy of glycogen utilization caused by an absence or deficiency of myophosphorylase. The muscle biopsy features include increased deposition of subsarcolemmal glycogen and absent phosphorylase histochemical staining of myofibers. We report the clinical and unique pathologic findings in three cases of McArdle's disease with prominent type 1 fiber atrophy.