An electron spin resonance study and antimicrobial activity of copper(II)-phenanthroline complexes

The antimicrobial activities of some copper(II) binary complexes with unsubstituted and different substituted phenanthroline ligands were investigated. A considerable increase in the biocidal activity of the ligands on being coordinated with the copper(II) ions was observed in terms of their minimum inhibitory concentration (MIC) values. EPR measurements were performed at room and low temperature with the aim of gaining an insight into the structure/activity relationship of these complexes. Subtle differences in the chemical arrangement result in appreciable differences in the antimicrobial activity. Copper(II) complexes with 2,9-dimethyl derivative phenanthrolines were observed to be more active against Staphylococcus aureus and Escherichia coli.