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The reactions of euthyroid and hyperthyroid glands to radioactive iodine
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048-1869, USA.
Background:
Researchers generally assume that the thyroid gland reacts more or less comparably to external irradiation and radioactive iodine.
Design:
The thyroid glands from 20 euthyroid patients and 20 hyperthyroid patients, all of which had been treated with radioactive iodine, were studied.
Results:
The two groups manifested different reactions. Almost all the euthyroid glands displayed a fibrotic atrophic pattern, whereas the glands from the Graves' disease patients showed more adenomatous and Hashimoto lesions than atrophy.
Conclusion:
Differences in the reactivity of normal and hyperplastic follicles may cause different reactions to treatment with radioactive iodine.
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