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Related Experiment Videos

Shiftwork and mortality from ischaemic heart disease

R McNamee1, K Binks, S Jones

  • 1Centre for Occupational Health, University of Manchester.

Occupational and Environmental Medicine
|June 1, 1996
PubMed
Summary

Shift work was not linked to increased ischemic heart disease (IHD) death risk. However, there was a reduced risk while actively shift working, with a rise after transitioning to day work, possibly due to health selection.

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Area of Science:

  • Occupational Health
  • Cardiovascular Epidemiology
  • Industrial Hygiene

Background:

  • Shift work is common in many industries, raising concerns about potential long-term health effects.
  • Ischaemic heart disease (IHD) remains a leading cause of mortality worldwide.
  • Understanding the relationship between occupational exposures like shift work and cardiovascular outcomes is crucial for public health.

Purpose of the Study:

  • To investigate the association between shift work and mortality from ischaemic heart disease (IHD).
  • To determine if prolonged or intermittent shift work influences the risk of dying from IHD.
  • To explore potential confounding factors and effect modification in this relationship.

Main Methods:

  • A nested case-control study design was employed within a cohort of male manual workers.

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  • Cases were defined as deaths from IHD (ICD 410-414) among cohort members aged 75 or under.
  • Work status (shift vs. day work) was determined from historical personnel records, with adjustments for covariates like BMI, blood pressure, and smoking.

    • Main Results:

    • No overall increased risk of IHD death was found associated with shift work.
    • A reduced risk of IHD death was observed during active periods of shift work.
    • An increased risk of IHD death was noted in the first five years after transitioning from shift work to day work.

    Conclusions:

    • Shift work itself does not appear to elevate the risk of death from ischaemic heart disease in this cohort.
    • Health-related selection may lead to underrepresentation of individuals with poorer cardiovascular health among long-term shift workers.
    • The findings suggest a complex interplay between shift work, cardiovascular health, and occupational transitions.