[The dynamic change in the levels of hydroxyproline in the burned wound]

Hydroxyproline, the main component of collagen, and morphological changes were assayed dynamically in the superficial second-degree burn wounds of rats, with the aim to investigate the change in collagen and its relationship with epidermization of burn wound. The results are as follows. Epidermal layer was lacking and higher levels of OHP were noted in the early days postburn, OHP peaked on the 3rd day, declined to normal on day 10 and day 14 postburn, the latter event was in pace with the epidermization of the burn wound. These results indicated that the levels of collagen in the superficial second-degree burn wound were mainly regulated by epidermal cells. Epidermization might inhibit over-proliferation of collagen. Epidermal derived factor (EDF) might be the main factor regulating the synthesis of collagen in the superficial second-degree burn wound.